In 1960, Bristol-Myers Squibb introduced Excedrin Extra Strength for headaches, the first multi-ingredient formulation headache treatment product. Contains 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine
1969 Excedrin PM The first headache and sleeping pill combined product. Contains 500 mg acetaminophen and 38 mg diphenhydramine citrate as a sleep aid, the same active ingredients as Tylenol PM, which was introduced several years later.
1998 Excedrin Migraine1 At the beginning of 1998, the FDA granted clearance to market Excedrin Migraine for the relief of migraine headache pain and associated symptoms.
Excedrin Migraine continued the trend of marketing pain products for specific types of pain, becoming the first migraine headache medication available to consumers without a prescription, even though it has identical ingredients to the regular Excedrin Extra Strength product, 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine.
2003 Excedrin Tension Headache Contains 500 mg acetaminophen and 65 mg caffeine.
2005 Excedrin Sinus Headache Contains 325 mg acetaminophen and 5 mg phenylephrine HCl as a decongestant.
2007 Excedrin Back and Body a dual-ingredient formula claiming that it “works two ways as a pain reliever and a pain blocker right where it hurts”. Contains 250 mg acetaminophen, 250 mg aspirin.
As with all medications containing acetaminophen, the use of alcohol with Excedrin carries a significant risk of hepatotoxicity. Additionally, aspirin usage is associated with increased risk of gastrointestinal bleeding.
